Recombinant human Relaxin-2 protein

Prorelaxin H2, also known as RLN2, belongs to the insulin gene superfamily. This family is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. RLN2 is a peptide hormone associated with a number of therapeutically relevant physiological effects, including regulation of collagen metabolism and multiple vascular control pathways. RLN1 and RLN2 share high sequence homology. Recombinant human RLN2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Prorelaxin H2 isoform, bA12D24.1.1, bA12D24.1.2, H2, RLXH2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

20.7 kDa (184aa)

Additionnal Information

Relaxin2, Prorelaxin H2 isoform, bA12D24.1.1, bA12D24.1.2, H2, RLXH2, ATGP1863-10 µg, ATGP1863-20 µg, ATGP1863-50 µg, ATGP1863-100 µg, ATGP1863-250 µg, ATGP1863-500 µg, ATGP1863-1 mg, ATGP1863-10, ATGP1863-20, ATGP1863-50, ATGP1863-100, ATGP1863-250, ATGP1863-500, ATGP1863-1

References & Citations

Hossain M A., et al. (2011) J Biol Chem. 286 (43) :37555-65.; ; Svendsen A M., et al. (2008) Mol Cell Endocrinol. 296:10-7.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_604390

Uniprot Accession Number

P04090

Species

Human

AA Sequence

DSWMEEV IKLCGRELVR AQIAICGMST WSKRSLSQED APQTPRPVAE IVPSFINKDT ETINMMSEFV ANLPQELKLT LSEMQPALPQ LQQHVPVLKD SSLLFEEFKK LIRNRQSEAA DSSPSELKYL GLDTHSRKKR QLYSALANKC CHVGCTKRSL ARFC