Recombinant human NTS protein

Neurotensin, also known as NTS, is a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. Recombinant human NTS protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Neurotensin neuromedin N, Neurotensin, neuromedin N, NMN-125, NN, NT, NT/N, NTS1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

19.9 kDa (172aa)

Additionnal Information

NTS, Neurotensin neuromedin N, Neurotensin, neuromedin N, NMN-125, NN, NT, NT/N, NTS1, ATGP1846-10 µg, ATGP1846-20 µg, ATGP1846-50 µg, ATGP1846-100 µg, ATGP1846-250 µg, ATGP1846-500 µg, ATGP1846-1 mg, ATGP1846-10, ATGP1846-20, ATGP1846-50, ATGP1846-100, ATGP1846-250, ATGP1846-500, ATGP1846-1

References & Citations

Bean A.J., et al. (1992) Neuroscience. 50:259-268; ; Quistgaard E.M., et al. (2009) Nat. Struct. Mol. Biol. 16:96-98;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Metabolism

NCBI Accession Number

NP_006174

Uniprot Accession Number

P30990

Species

Human

AA Sequence

SDSEE EMKALEADFL TNMHTSKISK AHVPSWKMTL LNVCSLVNNL NSPAEETGEV HEEELVARRK LPTALDGFSL EAMLTIYQLH KICHSRAFQH WELIQEDILD TGNDKNGKEE VIKRKIPYIL KRQLYENKPR RPYILKRDSY YY