Recombinant human BCMA/TNFRSF17 protein
Tumor necrosis factor receptor superfamily member 17, also known as TNFRSF17, is a member of the TNF-receptor superfamily. The open reading frame of the gene encoding TNFRSF17 predicts a 184 amino acid protein with a single transmembrane domain that has no homology with any known protein sequences. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. TNFRSF17 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. Recombinant human TNFRSF17 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Tumor necrosis factor receptor superfamily member 17, BCM, BCMA, CD269, B-cell maturation protein, TNFRSF13A
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
14.1 kDa (130aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Chae S C., et al. (2010) Mol Cells. 29 (1) : 21-8; ; Barone F., et al. (2009) Mucosal Immunol. 2 (6) : 495-503.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol,1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001183
Uniprot Accession Number
Q02223
Species
Human
AA Sequence
RKINSEP LKDEFKNTGS GLLGMANIDL EKSRTGDEII LPRGLEYTVE ECTCEDCIKS KPKVDSDHCF PLPAMEEGAT ILVTTKTNDY CKSLPAALSA TEIEKSISAR
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