Recombinant human HES7 protein

HES7 is a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene. Recombinant human HES7 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Transcription factor HES-7, Hairy and enhancer of split 7; bHLHb37; SCDO4

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

27 kDa (253aa)

Additionnal Information

HES7, Transcription factor HES-7, Hairy and enhancer of split 7; bHLHb37; SCDO4, ATGP1838-10 µg, ATGP1838-20 µg, ATGP1838-50 µg, ATGP1838-100 µg, ATGP1838-250 µg, ATGP1838-500 µg, ATGP1838-1 mg, ATGP1838-10, ATGP1838-20, ATGP1838-50, ATGP1838-100, ATGP1838-250, ATGP1838-500, ATGP1838-1

References & Citations

Sparrow DB, et al. (2008) . Hum Mol Genet. 1; ;17 (23) :3761-6.; ; Sillence D, et al. (2010) . Eur J Hum Genet. 18 (6) :674-9.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Ubiquitination

NCBI Accession Number

NP_001159439

Uniprot Accession Number

Q9BYE0

Species

Human

AA Sequence

MVTRDRA ENRDGPKMLK PLVEKRRRDR INRSLEELRL LLLERTRDQN LRNPKLEKAE ILEFAVGYLR ERSRVEPPAA AAPGVPRSPV QDAEALASCY LSGFRECLLR LAAFAHDASP AARAQLFSAL HGYLRPKPPR PKPVDPRPPA PRPSLDPAAP ALGPALHQRP PVHQGHPSPR CAWSPSLCSP RAGDSGAPAP LTGLLPPPPP PHRQDGAPKA PLPPPPAFWR PWP