Recombinant human IRGM protein
Immunity-related GTPase family M protein, also known as IRGM, is required for clearance of acute protozoan and bacterial infections. This protein functions in innate immune response probably through regulation of autophagy. It may regulate proinflammatory cytokine production and prevent endotoxemia upon infection and may also play a role in macrophages adhesion and motility. Recombinant human IRGM protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Immunity-related GTPase family M protein, IFI1, IRGM1, LRG-47, LRG47, MGC149263, MGC149264
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
20.1 kDa (180aa)
Additionnal Information
References & Citations
Singh S.B., et al. (2006) Science. 313:1438-1441; ; Parkes M., et al. (2007) Nat. Genet. 39:830-832;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001139277
Uniprot Accession Number
A1A4Y4
Species
Human
AA Sequence
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