Recombinant human IRGM protein

Immunity-related GTPase family M protein, also known as IRGM, is required for clearance of acute protozoan and bacterial infections. This protein functions in innate immune response probably through regulation of autophagy. It may regulate proinflammatory cytokine production and prevent endotoxemia upon infection and may also play a role in macrophages adhesion and motility. Recombinant human IRGM protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Immunity-related GTPase family M protein, IFI1, IRGM1, LRG-47, LRG47, MGC149263, MGC149264

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

20.1 kDa (180aa)

Additionnal Information

IRGM, Immunity-related GTPase family M protein, IFI1, IRGM1, LRG-47, LRG47, MGC149263, MGC149264, ATGP1833-10 µg, ATGP1833-20 µg, ATGP1833-50 µg, ATGP1833-100 µg, ATGP1833-250 µg, ATGP1833-500 µg, ATGP1833-1 mg, ATGP1833-10, ATGP1833-20, ATGP1833-50, ATGP1833-100, ATGP1833-250, ATGP1833-500, ATGP1833-1

References & Citations

Singh S.B., et al. (2006) Science. 313:1438-1441; ; Parkes M., et al. (2007) Nat. Genet. 39:830-832;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_001139277

Uniprot Accession Number

A1A4Y4

Species

Human

AA Sequence

KETLKIVSR TPVNITMAGD SGNGMSTFIS ALRNTGHEGK ASPPTELVKA TQRCASYFSS HFSNVVLWDL PGTGSATTTL ENYLMEMQFN RYDFIMVASA QFSMNHVMLA KTAEDMGKKF YIVWTKLDMD LSTGALPEVQ LLQIRENVLE NLQKERVCEY