Recombinant human LIN-7B protein
LIN7B, also known as VELI2, belongs to the Velis family. Velis are a family of small synaptic proteins that interact with other proteins at the post-synaptic density (PSD) of neuronal synapses. Velis contain the PDZ motif involved in recruiting cell adhesion molecules, receptors, and channels. Lin7B is ubiquitously expressed with high expression in brain, liver, and testis. It localized at the synaptic junctions in neurons. Lin7B bind to CASK, a neurexin-binding protein highly concentrated in synapses, and Mint1, a binding partner with a vesicle trafficking protein. Recombinant human LIN7B protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Protein lin-7 homolog B, LIN-7B, MALS-2, MALS2, VELI2, Mammalian lin-seven protein 2, Vertebrate lin-7 homolog 2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
25.3 kDa (230aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Okamoto M., et al. (1997) J Biol Chem. 272:31459-31464-293; ; Irie M., et al. (1999) Oncogene. 18:2811-2817.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_071448
Uniprot Accession Number
Q9HAP6
Species
Human
AA Sequence
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