Recombinant human ULBP-4/RAET1E protein

RAET1E belongs to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24. 2-q25. 3. RAET1E and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Recombinant human RAET1E protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Retinoic acid early transcript 1E, Lymphocyte effector toxicity activation ligand, NKG2D ligand 4, N2DL-4, NKG2DL4, RAE-1-like transcript 4, UL16-binding protein 4, LETAL, N2DL4, ULBP4

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

24.9 kDa (219aa)

Additionnal Information

ULBP4, RAET1E, NKG2D ligand 4, bA350J20.7, LETAL, N2DL-4, NKG2DL4, RAET1E2, RL-4, uLBP4, ATGP1820-10 µg, ATGP1820-20 µg, ATGP1820-50 µg, ATGP1820-100 µg, ATGP1820-250 µg, ATGP1820-500 µg, ATGP1820-1 mg, ATGP1820-10, ATGP1820-20, ATGP1820-50, ATGP1820-100, ATGP1820-250, ATGP1820-500, ATGP1820-1

References & Citations

McGilvray, R.W., et al. (2010) Int. J. Cancer 127 (6), 1412-1420; ; Antoun, A., et al. (2010) Hum. Immunol. 71 (6), 610-620;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_631904

Uniprot Accession Number

Q8TD07

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMHSLCFN FTIKSLSRPG QPWCEAQVFL NKNLFLQYNS DNNMVKPLGL LGKKVYATST WGELTQTLGE VGRDLRMLLC DIKPQIKTSD PSTLQVEMFC QREAERCTGA SWQFATNGEK SLLFDAMNMT WTVINHEASK IKETWKKDRG LEKYFRKLSK GDCDHWLREF LGHWEAMPEP TVSPVNASDI HWSSSSLPD