Recombinant human TRAX protein

TSNAX is a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. Recombinant human TSNAX protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Translin-associated protein X, TRAX

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

35 kDa (313aa) confirmed by MALDI-TOF

Additionnal Information

TSNAX, Translin-associated protein X, TRAX, , ATGP1819-10 µg, ATGP1819-20 µg, ATGP1819-50 µg, ATGP1819-100 µg, ATGP1819-250 µg, ATGP1819-500 µg, ATGP1819-1 mg, ATGP1819-010, ATGP1819-020, ATGP1819-050, ATGP1819-100, ATGP1819-250, ATGP1819-500, ATGP1819-01M

References & Citations

Chennathukuzhi VM, Kurihara Y, et al. (2001) . J Biol Chem. 276 (16) :13256-63.; ; Thomson PA, Wray NR, et al. (2005) . Mol Psychiatry. 10 (7) :657-68, 616.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% glycerol, 50 mM Imidazole, 0.1mM PMSF

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_005990.1

Uniprot Accession Number

Q99598

Species

Human

AA Sequence

MSNKEGS GGFRKRKHDN FPHNQRREGK DVNSSSPVML AFKSFQQELD ARHDKYERLV KLSRDITVES KRTIFLLHRI TSAPDMEDIL TESEIKLDGV RQKIFQVAQE LSGEDMHQFH RAITTGLQEY VEAVSFQHFI KTRSLISMDE INKQLIFTTE DNGKENKTPS SDAQDKQFGT WRLRVTPVDY LLGVADLTGE LMRMCINSVG NGDIDTPFEV SQFLRQVYDG FSFIGNTGPY EVSKKLYTLK QSLAKVENAC YALKVRGSEI PKHMLADVFS VKTEMIDQEE GIS