Recombinant human mannan-binding lectin/MBL2 protein

Mannose-binding protein C, also known as MBL2, is a member of the collectin family of patternrecognition molecules. MBL2 is a secreted glycoprotein that is synthesized as a 248 amino acid precursor. The Protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. Recombinant human MBL2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Mannose binding lectin 2, MBL, Collectin 1, Mannose-binding protein, COLEC1, MBP-C, MBP1, MBP, MBL

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

18 kDa (164aa)

Additionnal Information

MBL2, Mannose-binding protein C, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, ATGP1812-10 µg, ATGP1812-20 µg, ATGP1812-50 µg, ATGP1812-100 µg, ATGP1812-250 µg, ATGP1812-500 µg, ATGP1812-1 mg, ATGP1812-10, ATGP1812-20, ATGP1812-50, ATGP1812-100, ATGP1812-250, ATGP1812-500, ATGP1812-1

References & Citations

Sastry K., et al. (1989) J Exp Med. 170:1175.; ; Larsen F., et al. (2004) J Biol Chem. 279:21302.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 20% glycerol, 0.2M Nacl

Scientific Category

Immunology

NCBI Accession Number

NP_000233

Uniprot Accession Number

P11226

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSAASERKA LQTEMARIKK WLTFSLGKQV GNKFFLTNGE IMTFEKVKAL CVKFQASVAT PRNAAENGAI QNLIKEEAFL GITDEKTEGQ FVDLTGNRLT YTNWNEGEPN NAGSDEDCVL LLKNGQWNDV PCSTSHLAVC EFPI