Recombinant human CLNS1A protein
CLNS1A, also as known as, Methylosome subunit pICln, belongs to the pICln (TC 1. A. 47) family. CLNS1A protein has functions in multiple regulatory pathways. This protein interaction with Sm proteins inhibits their assembly on u RNA and interferes with snRNP biogenesis. It is Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. And this protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Recombinant human CLNS1A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Methylosome subunit pICln, CLCI, CLNS1B, Icln
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
28.7 kDa (261aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
References & Citations
Pu W.T., et al. (1999) Mol. Cell. Biol. 19:4113-4120; ; Friesen W.J., et al. (2001) Mol. Cell. Biol. 21:8289-8300;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 2mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_001284
Uniprot Accession Number
P54105
Species
Human
AA Sequence
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