Recombinant human SRA1 protein

Steroid receptor RNA activator 1, also known as SRA1, exists as both a RNA transcript and as stably expressed proteins. Also this protein mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2) . SRA1 enhances cellular proliferation and differentiation and promotes apoptosis in vivo. It may play a role in tumorigenesis. Recombinant human SRA1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Steroid receptor RNA activator 1, pp7684, SRA, SRAP, STRAA1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

18.7 kDa (170aa) confirmed by MALDI-TOF

Additionnal Information

SRA1, Steroid receptor RNA activator 1, pp7684, SRA, SRAP, STRAA1, ATGP1796-10 µg, ATGP1796-20 µg, ATGP1796-50 µg, ATGP1796-100 µg, ATGP1796-250 µg, ATGP1796-500 µg, ATGP1796-1 mg, ATGP1796-10, ATGP1796-20, ATGP1796-50, ATGP1796-100, ATGP1796-250, ATGP1796-500, ATGP1796-1

References & Citations

Lanz R B., et al. (1999) Cell. 97:17-27; ; Watanabe M., et al. (2001) EMBO J. 20: 1341-1352.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT

Scientific Category

Cancer

NCBI Accession Number

NP_001030312.2

Uniprot Accession Number

Q9HD15

Species

Human

AA Sequence

VGSGPAS GVEPTSFPVE SEAVMEDVLR PLEQALEDCR GHTRKQVCDD ISRRLALLQE QWAGGKLSIP VKKRMALLVQ ELSSHRWDAA DDIHRSLMVD HVTEVSQWMV GVKRLIAEKR SLFSEEAANE EKSAATAEKN HTIPGFQQAS