Recombinant human PHF11 protein

PHD finger protein 11, also known as PHF11, is a regulator of TH1-type cytokine gene expression. The reduction in PHF11 expression seen with an AD-associated genotype could contribute to the strong TH2 responses that characterize many allergic individuals. PHF11 are associated with increased total serum IgE levels, asthma, and severe atopic dermatitis (AD) in children. Although PHF11 includes a plant homeodomain, a motif often found in transcriptional regulators, the function of PHF11 has not been investigated. Recombinant human PHF11 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

PHD finger protein 11, APY, BCAP, IGEL, IGER, IGHER, NY-REN-34, NYREN34, RP11-185C18.3

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

39.7 kDa (351aa)

Additionnal Information

PHF11, PHD finger protein 11, APY, BCAP, IGEL, IGER, IGHER, NY-REN-34, NYREN34, RP11-185C18.3, ATGP1790-10 µg, ATGP1790-20 µg, ATGP1790-50 µg, ATGP1790-100 µg, ATGP1790-250 µg, ATGP1790-500 µg, ATGP1790-1 mg, ATGP1790-10, ATGP1790-20, ATGP1790-50, ATGP1790-100, ATGP1790-250, ATGP1790-500, ATGP1790-1

References & Citations

Clarke E., et al. (2008) J. Allergy Clin. Immunol. 121:1148-1154; ; Scanlan M.J., et al. (1999) Int. J. Cancer. 83:456-464;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_001035533

Uniprot Accession Number

Q9UIL8

Species

Human

AA Sequence

MAQASPPRPE RVLGASSPEA RPAQEALLLP TGVFQVAEKM EKRTCALCPK DVEYNVLYFA QSENIAAHEN CLLYSSGLVE CEDQDPLNPD RSFDVESVKK EIQRGRKLKC KFCHKRGATV GCDLKNCNKN YHFFCAKKDD AVPQSDGVRG IYKLLCQQHA QFPIIAQSAK FSGVKRKRGR KKPLSGNHVQ PPETMKCNTF IRQVKEEHGR HTDATVKVPF LKKCKEAGLL NYLLEEILDK VHSIPEKLMD ETTSESDYEE IGSALFDCRL FEDTFVNFQA AIEKKIHASQ QRWQQLKEEI ELLQDLKQTL CSFQENRDLM SSSTSISSLS Y