Recombinant human ASMT protein
ASMT belongs to the methyltransferase superfamily and is involved in melatonin biosynthesis. Expressed in brain, retina and pineal gland, ASMT functions to catalyze the final reaction in the synthesis of melatonin, specifically the conversion of S-adenosyl-L-methionine and N-acetylserotonin to S-adenosyl-L-homocysteine and melatonin. Recombinant human ASMT protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Acetylserotonin O-methyltransferase, HIOMT, HIOMTY
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
35.3 kDa (318aa)
Additionnal Information
References & Citations
Rodriguez I R., et al. (1994) J Biol Chem. 269:31969-31977.; ; Toma C., et al. (2007) Mol Psychiatry. 12:977-979.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1M urea, 10% glycerol
Scientific Category
Metabolism
NCBI Accession Number
AAH01620
Uniprot Accession Number
P46597
Species
Human
AA Sequence
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