Recombinant mouse Galectin-8/LGALS8 protein
LGALS8, also known as prostate-specific membrane antigen (PCTA1), is an additional prostate-specific antigen that is overexpressed only in malignant tumors and therefore is a more specific identifier of malignancies. It is a member of the galectin gene family which mediates both cell-cell and cell matrix interactions in a manner similar to the selectin subgroup of C-type lectins. Recombinant mouse LGALS8 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Measured by its ability to agglutinate human red blood cells. The ED50 range for this effect is ≤ 2 µg/mL.
Product Name Alternative
Lectin galactose binding soluble 8, Lgals-8
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Bioactivity
Measured by its ability to agglutinate human red blood cells. The ED50 range for this effect is ≤ 2 µg/mL.
Molecular Weight
38.6 KDa (339aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Kobayashi T., et al. (2010) Leukemia. 24 (4) :843-50.; ; Streetly MJ., et al. (2010) Blood. 115 (19) :3939-48.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol,1mM DTT
Scientific Category
Cancer
NCBI Accession Number
NP_061374
Uniprot Accession Number
Q9JL15
Species
Mouse
AA Sequence
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