Recombinant human TSC22D3 protein
TSC22 domain family protein 3, also known as TSC22D3, protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Recombinant human TSC22D3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
TSC22 domain family protein 3, DIP, DSIPI, GILZ, hDIP, TSC-22R
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
17.2 kDa (157aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Asselin-Labat M.-L., et al. (2004) Blood. 104:215-223; ; Berrebi D., et al. (2003) Blood. 101:729-738
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_004080
Uniprot Accession Number
Q99576
Species
Human
AA Sequence
MNTEMYQ TPMEVAVYQL HNFSISFFSS LLGGDVVSVK LDNSASGASV VAIDNKIEQA MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Mouse Monoclonal Desmoglein-3 Antibody (rDSG3/8611) [Alexa Fluor 647]](https://cdn.genprice.uk/genprice/genprice2.png)
Mouse Monoclonal Desmoglein-3 Antibody (rDSG3/8611) [Alexa Fluor 647]
N⁶- Benzyladenosine- 5'- O- triphosphate (6-Bn-ATP), sodium salt
![Rabbit Polyclonal SUHW2 Antibody [mFluor Violet 610 SE]](https://cdn.genprice.uk/genprice/genprice5.png)