Recombinant human UTP23 protein
RRNA-processing protein uTP23 homolog, also known as uTP23, is a small subunit (SSu) processome component. The SSu processome is a complex involved in ribosome biogenesis and is required for pre-18S rRNA maturation. uTP23 is required for the first three cleavage steps in 18S rRNA maturation. In addition, single-point mutations in the conserved putative active site of utp24 but not utp23 abrogate its function in ribosome biogenesis. Recombinant human uTP23 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
RRNA-processing protein uTP23 homolog, C8orf53
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
30.8 kDa (272aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Bleichert F., et al. (2006) Proc Natl Acad Sci uSA. 103 (25) :9464-9; ; Bernstein K A., et al. (2004) Eukaryotic Cell. 3: 1619-1626.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% glycerol,1mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_115710
Uniprot Accession Number
Q9BRU9
Species
Human
AA Sequence
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