Recombinant human HAND1 protein

HAND1 belongs to the basic helix-loop-helix family of transcription factors. This protein is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. Recombinant human HAND1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Heart and neural crest derivatives-expressed protein 1, bHLHa27, eHand, Hxt, Thing1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

26 kDa (238aa)

Additionnal Information

HAND1, Heart and neural crest derivatives-expressed protein 1, bHLHa27, eHand, Hxt, Thing1, ATGP1739-10 µg, ATGP1739-20 µg, ATGP1739-50 µg, ATGP1739-100 µg, ATGP1739-250 µg, ATGP1739-500 µg, ATGP1739-1 mg, ATGP1739-10, ATGP1739-20, ATGP1739-50, ATGP1739-100, ATGP1739-250, ATGP1739-500, ATGP1739-1

References & Citations

Scott IC., et al. (2000) . Mol Cell Biol. 20 (2) :530-41.; ; Srivastava D. Trends Cardiovasc Med. 1999 Jan-Feb; ;9 (1-2) :11-8.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Development

NCBI Accession Number

NP_004812

Uniprot Accession Number

O96004

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMNLVGSY AHHHHHHHPH PAHPMLHEPF LFGPASRCHQ ERPYFQSWLL SPADAAPDFP AGGPPPAAAA AATAYGPDAR PGQSPGRLEA LGGRLGRRKG SGPKKERRRT ESINSAFAEL RECIPNVPAD TKLSKIKTLR LATSYIAYLM DVLAKDAQSG DPEAFKAELK KADGGRESKR KRELQQHEGF PPALGPVEKR IKGRTGWPQQ VWALELNQ