Recombinant human HAND1 protein
HAND1 belongs to the basic helix-loop-helix family of transcription factors. This protein is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. Recombinant human HAND1 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Heart and neural crest derivatives-expressed protein 1, bHLHa27, eHand, Hxt, Thing1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
26 kDa (238aa)
Additionnal Information
References & Citations
Scott IC., et al. (2000) . Mol Cell Biol. 20 (2) :530-41.; ; Srivastava D. Trends Cardiovasc Med. 1999 Jan-Feb; ;9 (1-2) :11-8.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Development
NCBI Accession Number
NP_004812
Uniprot Accession Number
O96004
Species
Human
AA Sequence
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