Recombinant human Kallikrein 7/KLK7 protein

KLK7 is a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikreins are biomarkers for cancer. The protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. KLK7 may play a role in cancer invasion and metastasis, and increased expression of this protein is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Recombinant human KLK7 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Stratum corneum chymotryptic enzyme, Serine protease 6, SCCE, PRSS6, KLK7, Kallikrein-7 isoform 2, Kallikrein-7, Kallikrein related peptidase 7, HK7

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

27.1 kDa (249aa)

Additionnal Information

Stratum corneum chymotryptic enzyme, Serine protease 6, SCCE, PRSS6, KLK7, Kallikrein-7 isoform 2, Kallikrein-7, Kallikrein related peptidase 7, HK7, ATGP1737-10 µg, ATGP1737-20 µg, ATGP1737-50 µg, ATGP1737-100 µg, ATGP1737-250 µg, ATGP1737-500 µg, ATGP1737-1 mg, ATGP1737-010, ATGP1737-020, ATGP1737-050, ATGP1737-100, ATGP1737-250, ATGP1737-500, ATGP1737-01M

References & Citations

Talieri, M., et al. (2011) Anticancer Res. 31 (9), 3093-3100; ; Ramani, V.C., et al. (2011) Biochim. Biophys. Acta 1813 (8), 1525-1531

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M uREA, 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_005037

Uniprot Accession Number

P49862

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMIIDGA PCARGSHPWQ VALLSGNQLH CGGVLVNERW VLTAAHCKMN EYTVHLGSDT LGDRRAQRIK ASKSFRHPGY STQTHVNDLM LVKLNSQARL SSMVKKVRLP SRCEPPGTTC TVSGWGTTTS PDVTFPSDLM CVDVKLISPQ DCTKVYKDLL ENSMLCAGIP DSKKNACNGD SGGPLVCRGT LQGLVSWGTF PCGQPNDPGV YTQVCKFTKW INDTMKKHR