Recombinant human Kallikrein 7/KLK7 protein
KLK7 is a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikreins are biomarkers for cancer. The protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. KLK7 may play a role in cancer invasion and metastasis, and increased expression of this protein is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Recombinant human KLK7 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Stratum corneum chymotryptic enzyme, Serine protease 6, SCCE, PRSS6, KLK7, Kallikrein-7 isoform 2, Kallikrein-7, Kallikrein related peptidase 7, HK7
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
27.1 kDa (249aa)
Additionnal Information
References & Citations
Talieri, M., et al. (2011) Anticancer Res. 31 (9), 3093-3100; ; Ramani, V.C., et al. (2011) Biochim. Biophys. Acta 1813 (8), 1525-1531
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M uREA, 10% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_005037
Uniprot Accession Number
P49862
Species
Human
AA Sequence
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