Recombinant human ABI3 protein

ABI3, also as known as ABI gene family member 3, belongs to the ABI family. This protein is a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The Abi family members are thought to negatively regulate cell growth and transformation, including cellular transformation through v-Abl as well as mediate cell motility by regulating actin polymerization in lamellipodia and filopodia. ABI3 inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase.

Product Specifications

Product Name Alternative

ABI family member 3, ABI family, member 3, NESH, SSH3BP3

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

41.4 kDa (389aa)

Additionnal Information

ABI3, ABI family member 3, ABI family, member 3, NESH, SSH3BP3, ATGP1733-10 µg, ATGP1733-20 µg, ATGP1733-50 µg, ATGP1733-100 µg, ATGP1733-250 µg, ATGP1733-500 µg, ATGP1733-1 mg, ATGP1733-10, ATGP1733-20, ATGP1733-50, ATGP1733-100, ATGP1733-250, ATGP1733-500, ATGP1733-1

References & Citations

Ichigotani Y., et al. (2002) Cancer Res. 62:2215-2219; ; Miyazaki K, et al. (2000) Biochim Biophys Acta 1493 (1-2) : 237-41.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_057512

Uniprot Accession Number

Q9P2A4

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAELQQL QEFEIPTGRE ALRGNHSALL RVADYCEDNY VQATDKRKAL EETMAFTTQA LASVAYQVGN LAGHTLRMLD LQGAALRQVE ARVSTLGQMV NMHMEKVARR EIGTLATVQR LPPGQKVIAP ENLPPLTPYC RRPLNFGCLD DIGHGIKDLS TQLSRTGTLS RKSIKAPATP ASATLGRPPR IPEPVHLPVV PDGRLSAASS ASSLASAGSA EGVGGAPTPK GQAAPPAPPL PSSLDPPPPP AAVEVFQRPP TLEELSPPPP DEELPLPLDL PPPPPLDGDE LGLPPPPPGF GPDEPSWVPA SYLEKVVTLY PYTSQKDNEL SFSEGTVICV TRRYSDGWCE GVSSEGTGFF PGNYVEPSC