Recombinant human MOCS2 protein
MOCS2 is a heterotetrameric synthase composed of two small (MOCS2A) and two large (MOCS2B) subunits. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. MOCS2 functions in the second step of the synthesis of molybdenum cofactor or molybdopterin (MPT) . It catalyzes the formation of MPT from precursor Z by incorporating a dithiolene functional group. Recombinant human MOCS2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Molybdenum cofactor synthesis 2, molybdenum cofactor synthesis 2, MCBPE, MOCO1, MOCS2A, MOCS2B, MPTS
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
25 kDa (224aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Leimkuhler S., et al. (2005) Hum Genet. 117: 565-570; ; Reiss J., et al. (1999) Hum Genet . 64: 706-711.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 50% glycerol,1mM DTT
Scientific Category
Metabolism
NCBI Accession Number
NP_004522
Uniprot Accession Number
O96007
Species
Human
AA Sequence
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