Recombinant human TNFRSF7/CD27 protein

TNFRSF7, also known as CD27, is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. Recombinant human CD27 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, TNFRSF7, T cell antivation antigen S152, TP55

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

21.8 kDa (196aa)

Additionnal Information

CD27, CD27 antigen, S152, T14, TNFRSF7, Tp55, ATGP1710-10 µg, ATGP1710-20 µg, ATGP1710-50 µg, ATGP1710-100 µg, ATGP1710-250 µg, ATGP1710-500 µg, ATGP1710-1 mg, ATGP1710-10, ATGP1710-20, ATGP1710-50, ATGP1710-100, ATGP1710-250, ATGP1710-500, ATGP1710-1

References & Citations

Gravestein L.A., et al. (1998) Eur. J. Immunol. 28:2208-2216; ; Prasad K.V.S., et al. (1997) Proc. Natl. Acad. Sci. u.S.A. 94:6346-6351

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_001233

Uniprot Accession Number

P26842

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMTPAPK SCPERHYWAQ GKLCCQMCEP GTFLVKDCDQ HRKAAQCDPC IPGVSFSPDH HTRPHCESCR HCNSGLLVRN CTITANAECA CRNGWQCRDK ECTECDPLPN PSLTARSSQA LSPHPQPTHL PYVSEMLEAR TAGHMQTLAD FRQLPARTLS THWPPQRSLC SSDFIR