Recombinant human NIPP1/PPP1R8 protein
PPP1R8, also as known as NIPP-1, is the RNA-binding subunit of a major species of protein phosphatase-1 in the nucleus. This enzyme is inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1) . It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. Recombinant human PPP1R8 protein, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Nuclear inhibitor of protein phosphatase 1, ARD-1, ARD1, NIPP-1, NIPP1, PRO2047
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
39.5 kDa (359aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Jin Q., et al. (1999) Biochem. J. 342:13-19; ; Beullens M., et al. (2000) Biochem. J. 352:651-658
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% glycerol, 2mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_054829.2
Uniprot Accession Number
Q12972
Species
Human
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