Recombinant human CREG/CREG1 protein
CREG1 both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. This protein antagonizes transcriptional activation and cellular transformation by E1A. It shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. CREG1 may contribute to the transcriptional control of cell growth and differentiation. Recombinant human CREG1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Cellular repressor of E1A-stimulated genes 1, CREG
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
23.6 kDa (213aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Wang, N., et al. (2011) Atherosclerosis 218 (2), 543-551; ; Han, Y., et al. (2011) J. Mol. Cell. Cardiol. 50 (4), 723-730
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_003842
Uniprot Accession Number
O75629
Species
Human
AA Sequence
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