Recombinant human CD161/KLRB1 protein

Killer cell lectin-like receptor subfamily B member 1, also known as KLRB1, plays an inhibitory role on natural killer (NK) cells cytotoxicity. Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. Recombinant human KLRB1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Killer cell lectin like receptor B1, Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, NKR-P1A, Natural killer cell surface protein P1A, CD161, CLEC5B, NKRP1A, NKR-P1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

21.0 kDa (183aa)

Additionnal Information

CD161, Killer cell lectin-like receptor subfamily B member 1, p35-2, STX4A, ATGP1678-10 µg, ATGP1678-20 µg, ATGP1678-50 µg, ATGP1678-100 µg, ATGP1678-250 µg, ATGP1678-500 µg, ATGP1678-1 mg, ATGP1678-10, ATGP1678-20, ATGP1678-50, ATGP1678-100, ATGP1678-250, ATGP1678-500, ATGP1678-1

References & Citations

Lanier L.L., et al. (1994) J. Immunol. 153:2417-2428; ; Christiansen D., et al. (2006) Xenotransplantation. 13:440-446

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_002249

Uniprot Accession Number

Q12918

Species

Human

AA Sequence

QKSSIE KCSVDIQQSR NKTTERPGLL NCPIYWQQLR EKCLLFSHTV NPWNNSLADC STKESSLLLI RDKDELIHTQ NLIRDKAILF WIGLNFSLSE KNWKWINGSF LNSNDLEIRG DAKENSCISI SQTSVYSEYC STEIRWICQK ELTPVRNKVY PDS