Recombinant human TIRAP protein

TIRAP (toll-interleukin1 receptor (TIR) domain containing adaptor protein) contains 1 TIR domain. This protein is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Adapter protein, TIRAP, is involved in TLR2 and TLR4 signaling pathways in the innate immune response. Recombinant human TIRAP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Toll-interleukin1 receptor (TIR) domain containing adaptor protein, BACTS1, Mal, wyatt

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

26.3 kDa (244aa) confirmed by MALDI-TOF

Additionnal Information

TIRAP, toll-interleukin1 receptor (TIR) domain containing adaptor protein, BACTS1, Mal, wyatt, ATGP1675-10 µg, ATGP1675-20 µg, ATGP1675-50 µg, ATGP1675-100 µg, ATGP1675-250 µg, ATGP1675-500 µg, ATGP1675-1 mg, ATGP1675-10, ATGP1675-20, ATGP1675-50, ATGP1675-100, ATGP1675-250, ATGP1675-500, ATGP1675-1

References & Citations

Semaan N., et al. (2008) J. Immunol. 180:3485-3491; ; Nagpal K., et al. (2009) J. Biol. Chem. 284:25742-25748

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% glycerol,2mM DTT

Scientific Category

Immunology

NCBI Accession Number

NP_001034750

Uniprot Accession Number

P58753

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMASSTSL PAPGSRPKKP LGKMADWFRQ TLLKKPKKRP NSPESTSSDA SQPTSQDSPL PPSLSSVTSP SLPPTHASDS GSSRWSKDYD VCVCHSEEDL VAAQDLVSYL EGSTASLRCF LQLRDATPGG AIVSELCQAL SSSHCRVLLI TPGFLQDPWC KYQMLQALTE APGAEGCTIP LLSGLSRAAY PPELRFMYYV DGRGPDGGFR QVKEAVMRYL QTLS