Recombinant human Syntaxin 4 protein

Syntaxin 4, also known as STX4, belongs to thesyntaxin/epimorphin family of proteins. Syntaxin family is cellular receptors for transport vesicles which participate in exocytosis in neutrophils. Syntaxin 4 is crucial for normal insulin-stimulated glucose uptake in skeletal muscle and decreases in Syntaxin 4 protein levels result in reduction of whole-body insulin-stimulated glucose metabolism. Recombinant human STX4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Syntaxin 4, p35-2, STX4A

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

34.7 kDa (300aa) confirmed by MALDI-TOF

Additionnal Information

Syntaxin4, Syntaxin 4, p35-2, STX4A, ATGP1667-10 µg, ATGP1667-20 µg, ATGP1667-50 µg, ATGP1667-100 µg, ATGP1667-250 µg, ATGP1667-500 µg, ATGP1667-1 mg, ATGP1667-10, ATGP1667-20, ATGP1667-50, ATGP1667-100, ATGP1667-250, ATGP1667-500, ATGP1667-1

References & Citations

Yang C., et al. (2001) J Clin Invest. 107: 1311-1318; ; Bennett M K., et al. (1993) Cell. 74: 863-873.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 40% glycerol,1mM DTT

Scientific Category

Signal Transduction

NCBI Accession Number

NP_004595

Uniprot Accession Number

Q12846

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMMRDRT HELRQGDDSS DEEDKERVAL VVHPGTARLG SPDEEFFHKV RTIRQTIVKL GNKVQELEKQ QVTILATPLP EESMKQELQN LRDEIKQLGR EIRLQLKAIE PQKEEADENY NSVNTRMRKT QHGVLSQQFV ELINKCNSMQ SEYREKNVER IRRQLKITNA GMVSDEELEQ MLDSGQSEVF VSNILKDTQV TRQALNEISA RHSEIQQLER SIRELHDIFT FLATEVEMQG EMINRIEKNI LSSADYVERG QEHVKTALEN QKKARKKKVL