Recombinant human TMOD3 protein
TMOD3 belongs to the tropomodulin family. Regulation of the actin cytoskeleton by filament capping proteins is critical to myriad dynamic cellular functions. The ability of these proteins to bind both filaments as well as monomers is often central to their cellular functions. The ubiquitous pointed end capping protein TMOD3 acts as a negative regulator of cell migration, yet mechanisms behind its cellular functions are not understood. Recombinant human TMOD3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Tropomodulin-3, Tropomodulin 3, u-Tmod, uTMOD, ubiquitous tropomodulin
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
42 kDa (376aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Fischer RS., et al. (2006) J Biol Chem. 2006 Nov 24; ;281 (47) :36454-65. Epub 2006 Oct 1.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_055362
Uniprot Accession Number
Q9NYL9
Species
Human
AA Sequence
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