Recombinant human VPS26A protein
VPS26A, also known as vacuolar protein sorting-associated protein 26A, is essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also this protein is required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) . Recombinant human VPS26A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
VPS26 retromer complex component A, Vacuolar protein sorting-associated protein 26A, Vesicle protein sorting 26A, hVPS26, VPS26, Hbeta58, PEP8A
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
40.6 kDa (350aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Verges M., et al. (2004) Nat. Cell Biol. 6:763-769; ; Gullapalli A., et al. (2006) Mol. Biol. Cell. 17:1228-1238
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.15M NaCl
Scientific Category
Transportation
NCBI Accession Number
NP_004887
Uniprot Accession Number
O75436
Species
Human
AA Sequence
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