Recombinant human SH3BGRL protein
SH3BGRL, also known as SH3 domain-binding glutamic acid-rich-like protein, is a member of the human SH3BGR family. SH3BGRL gene located to chromosome Xq13. 3 encodes for a small protein of 114 amino acids, which is apparently widely expressed in many tissues including liver and blood. SH3BGRL protein features a prolinerich sequence (PLPPQIF), which contains both the SH3 binding (PXXP) 3 and the Homer EVH1 binding (PPXXF) 4 motif. This proline-rich region is highly conserved in human SH3BGR family and was expected to be functionally important. Recombinant human SH3BGRL protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
SH3 domain-binding glutamic acid-rich-like protein, SH3BGR
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
15.3 kDa (138aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Egeo A., et al. (1998) Biochem. Biophys. Res. Commun. 247:302-306; ; Yin L., et al. (2006) Proteins. 61:213-216
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.15M NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_003013
Uniprot Accession Number
O75368
Species
Human
AA Sequence
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