Recombinant human DNAJC12 protein
DNAJC12, also known as JDP1, is a member of the DnaJ/Hsp40 family. The members of the DnaJ/Hsp40 proteins are highly conserved through evolution, expressed in several tissues and act as co-chaperone regulating protein folding, transport, translational initiation and gene expression. DnaJC12 may play a role in protein folding and export and is thought to be involved in estrogen control and the development of breast cancer. This protein is expressed at high levels in brain, heart, and testis, and at reduced levels in kidney and stomach. Recombinant human DNAJC12 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
DnaJ (Hsp40) homolog subfamily C member 12, DnaJ (Hsp40) homolog, subfamily C, member 12, JDP1, RP11-57G10.2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
26kDa (222aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
References & Citations
De Bessa SA, et al. (2006) J Mol Med. 17 (2) :363-7.; ; Mahlknecht, u., et al. (2009) Int. J. Mol. Med. 23: 245-252.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 100 mM NaCl
Scientific Category
Heat Shock Proteins
NCBI Accession Number
NP_068572
Uniprot Accession Number
Q9UKB3
Species
Human
AA Sequence
Frequently Asked Questions
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