Recombinant human PTGR1 protein
PTGR1, also known as LTB4DH, belongs to the NADP-dependent oxidoreductase L4BD family. This enzyme catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. It is highly expressed in the kidney, liver, and intestine but not in leukocytes. Recombinant human PTGR1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Prostaglandin reductase 1, LTB4DH, PGR1, ZADH3
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
38.6 kDa (354aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Yokomizo T., et al. (1996) J. Biol. Chem. 271:2844-2850; ; Tai, H.H., et al. (2002) . Prostaglandins Other Lipid Mediat. 68-69: 483-493.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 10% glycerol, 1mM DTT, 200 mM NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_036344
Uniprot Accession Number
Q14914
Species
Human
AA Sequence
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