Recombinant human MUTED protein

Muted homolog, also known as MuTED, is involved in the development of lysosome related organelles, such as melanosomes and platelet dense granules. MuTED interacts with pallidin, dystrobrevin binding protein 1 and CNO/cappuccino. It is part of the biogenesis of lysosome related organelles complex 1 (BLOC1) . Also, MuTED is ubiquitously expressed with higher levels in brain, bone marrow, kidney, and liver and lower levels in skeletal muscle. Recombinant human MuTED protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Muted homolog, Mu

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

24 kDa (210aa) confirmed by MALDI-TOF

Additionnal Information

MUTED, Muted homolog, Mu, ATGP1631-10 µg, ATGP1631-20 µg, ATGP1631-50 µg, ATGP1631-100 µg, ATGP1631-250 µg, ATGP1631-500 µg, ATGP1631-1 mg, ATGP1631-10, ATGP1631-20, ATGP1631-50, ATGP1631-100, ATGP1631-250, ATGP1631-500, ATGP1631-1

References & Citations

Ciciotte S L., et al. (2003) Blood. 101: 4402-4407; ; Starcevic M., et al. (2004) J Biol Chem. 279: 28393-28401.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 40% glycerol,2mM DTT, 0.1mM PMSF, 1mM EDTA

Scientific Category

Signal Transduction

NCBI Accession Number

NP_958437

Uniprot Accession Number

Q8TDH9

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSGGGTE TPVGCEAAPG GGSKKRDSLG TAGSAHLIIK DLGEIHSRLL DHRPVIQGET RYFVKEFEEK RGLREMRVLE NLKNMIHETN EHTLPKCRDT MRDSLSQVLQ RLQAANDSVC RLQQREQERK KIHSDHLVAS EKQHMLQWDN FMKEQPNKRA EVDEEHRKAM ERLKEQYAEM EKDLAKFSTF