Recombinant human RANGRF protein

RANGRF is a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1. 5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. Recombinant human RANGRF protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

RAN guanine nucleotide release factor, HSPC165, HSPC236, MOG1, RANGNRF

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

23 kDa (210aa) confirmed by MALDI-TOF

Additionnal Information

RANGRF, RAN guanine nucleotide release factor, HSPC165, HSPC236, MOG1, RANGNRF, ATGP1620-10 µg, ATGP1620-20 µg, ATGP1620-50 µg, ATGP1620-100 µg, ATGP1620-250 µg, ATGP1620-500 µg, ATGP1620-1 mg, ATGP1620-10, ATGP1620-20, ATGP1620-50, ATGP1620-100, ATGP1620-250, ATGP1620-500, ATGP1620-1

References & Citations

Olesen, M.S., et al. (2011) Can J Cardiol 27 (4), 523; ; Kattygnarath, D., et al. (2011) Circ Cardiovasc Genet 4 (3), 261-268.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.15M NaCl, 1mM DTT

Scientific Category

Signal Transduction

NCBI Accession Number

NP_057576

Uniprot Accession Number

Q9HD47

Species

Human

AA Sequence

MEPTRD CPLFGGAFSA ILPMGAIDVS DLRPVPDNQE VFCHPVTDQS LIVELLELQA HVRGEAAARY HFEDVGGVQG ARAVHVESVQ PLSLENLALR GRCQEAWVLS GKQQIAKENQ QVAKDVTLHQ ALLRLPQYQT DLLLTFNQPP PDNRSSLGPE NLSPAPWSLG DFEQLVTSLT LHDPNIFGPQ