Recombinant human MEMO1 protein
MEMO1 (Mediator of ErbB2-driven cell motility 1), also known as C2orf4 or NS5ATP7, belongs to the uPF0103 family. MEMO1 control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. It is required for breast carcinoma cell migration, suggesting an important role in tumorigenesis. Also, it controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. Recombinant human MEMO1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Protein MEMO1, C2orf4, CGI-27, MEMO, NS5ATP7
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
36.4 kDa (322aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Marone R., et al. (2004) Nat. Cell Biol. 6:515-522; ; Zaoui K., et al. (2010) Proc. Natl. Acad. Sci. u.S.A. 107:18517-18522
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 50% glycerol, 5mM DTT, 300 mM NaCl, 2mM EDTA
Scientific Category
Signal Transduction
NCBI Accession Number
NP_057039
Uniprot Accession Number
Q9Y316
Species
Human
AA Sequence
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