Recombinant human OVCA2 protein

Ovarian tumor suppressor candidate 2, also known as OVCA2, belongs to the uPF0483 family. It is ubiquitously expressed and its expression is regulated by retinoids. OVCA2 interacts with apoptosis-related protein Bag-1, indicating that this protein may participate in cell proliferation. Due to its structural and catalytic characteristics, OVCA2 is thought to act as a serine-hydrolase and, because of its reduced expression in ovarian and other tumor cell lines, it may play a role in tumor suppression. Recombinant human OVCA2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Ovarian tumor suppressor candidate 2, Ovarian cancer-associated gene 2 protein

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

26.9 kDa (251aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Additionnal Information

OVCA2, Ovarian tumor suppressor candidate 2, Ovarian cancer-associated gene 2 protein, ATGP1618-10 µg, ATGP1618-20 µg, ATGP1618-50 µg, ATGP1618-100 µg, ATGP1618-250 µg, ATGP1618-500 µg, ATGP1618-1 mg, ATGP1618-10, ATGP1618-20, ATGP1618-50, ATGP1618-100, ATGP1618-250, ATGP1618-500, ATGP1618-1

References & Citations

Azizi A A., et al. (2006) Cancer Lett. 241 (2) :235-49.; ; Prowse A H., et al. (2002) Int J Cancer. 99 (2) : 185-92.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT

Scientific Category

Cancer

NCBI Accession Number

NP_543012

Uniprot Accession Number

Q8WZ82

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMAAQRP LRVLCLAGFR QSERGFREKT GALRKALRGR AELVCLSGPH PVPDPPGPEG ARSDFGSCPP EEQPRGWWFS EQEADVFSAL EEPAVCRGLE ESLGMVAQAL NRLGPFDGLL GFSQGAALAA LVCALGQAGD PRFPLPRFIL LVSGFCPRGI GFKESILQRP LSLPSLHVFG DTDKVIPSQE SVQLASQFPG AITLTHSGGH FIPAAAPQRQ AYLKFLDQFA E