Recombinant human TCEAL7 protein
TCEAL7 plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. It associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. This protein regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres) and telomerase-positive cell lines. Recombinant human TCEAL7 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Transcription elongation factor A (SII) -like 7, MPMGp800C04260Q003
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
14.8 kDa (124aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Lafferty-Whyte, K., et al. (2010) Neoplasia 12 (5), 405-414; ; Rattan, R., et al. (2010) Oncogene 29 (9), 1362-1373
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 50% glycerol, 0.2M NaCl, 2mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_689491
Uniprot Accession Number
Q9BRU2
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMQKPCK ENEGKPKCSV PKREEKRPYG EFERQQTEGN FRQRLLQSLE EFKEDIDYRH FKDEEMTREG DEMERCLEEI RGLRKKFRAL HSNHRHSRDR PYPI
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