Recombinant human SIL1 protein
Nucleotide exchange factor, also known as SIL1, is a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Recombinant human SIL1 protein, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Nucleotide exchange factor SIL1, BAP, MSS, uLG5
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
50 kDa (439aa)
Additionnal Information
References & Citations
Chung KT., et al. (2002) J Biol Chem. 277 (49) :47557-63.; ; Senderek J., et al. (2005) Nat Genet. 37 (12) : 1312-4.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol
Scientific Category
Heat Shock Proteins
NCBI Accession Number
NP_071909
Uniprot Accession Number
Q9H173
Species
Human
AA Sequence
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