Recombinant human GAP-43 protein
Growth associated protein 43, also known as GAP43, is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. It is present at high levels in neuronal growth cones during development and axonal regeneration. GAP43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system. Also, GAP43 plays an essential role in the maintenance mechanism of long-term potentiation (LTP) . Recombinant human GAP43 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Growth associated protein 43, Neuromodulin, B-50, PP46
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by BCA assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
27.3 kDa (262aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
References & Citations
Dent E W., et al. (1998) J Neurobiol. 35:287-299.; ; Neve R L., et al. (1998) J Neurosci. 18: 7757-7767.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_002036.1
Uniprot Accession Number
P17677
Species
Human
AA Sequence
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