Recombinant human FGFR1OP protein

FGFR1OP, also known as FGFR1 oncogene partner, belongs to the FGFR1OP family. This protein is a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t (6;8) (q27; p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Recombinant human FGFR1OP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

FGFR1 oncogene partner, FOP

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

43.5 kDa (403aa) confirmed by MALDI-TOF

Additionnal Information

FGFR1OP, FGFR1 oncogene partner, FOP, ATGP1565-10 µg, ATGP1565-20 µg, ATGP1565-50 µg, ATGP1565-100 µg, ATGP1565-250 µg, ATGP1565-500 µg, ATGP1565-1 mg, ATGP1565-10, ATGP1565-20, ATGP1565-50, ATGP1565-100, ATGP1565-250, ATGP1565-500, ATGP1565-1

References & Citations

Yan X., et al. (2006) Mol. Biol. Cell. 17:634-644; ; Mikolajka A., et al. (2006) J. Mol. Biol. 359:863-875

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT

Scientific Category

Cell Cycle

NCBI Accession Number

NP_919410

Uniprot Accession Number

O95684

Species

Human

AA Sequence

MAATAA AVVAEEDTEL RDLLVQTLEN SGVLNRIKAE LRAAVFLALE EQEKVENKTP LVNESLKKFL NTKDGRLVAS LVAEFLQFFN LDFTLAVFQP ETSTLQGLEG RENLARDLGI IEAEGTVGGP LLLEVIRRCQ QKEKGPTTGE GALDLSDVHS PPKSPEGKTS AQTTPSKKAN DEANQSDTSV SLSEPKSKSS LHLLSHETKI GSFLSNRTLD GKDKAGLCPD EDDMEGDSFF DDPIPKPEKT YGLRKEPRKQ AGSLASLSDA PPLKSGLSSL AGAPSLKDSE SKRGNTVLKD LKLISDKIGS LGLGTGEDDD YVDDFNSTSH RSEKSEISIG EEIEEDLSVE IDDINTSDKL DDLTQDLTVS QLSDVADYLE DVA