Recombinant human JAM-A/F11R protein
F11R, also known as CD321, belongs to the immunoglobulin superfamily. It seems to plays a role in epithelial tight junction formation. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. F11R protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Recombinant human F11R protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by BCA assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
25.8 kDa (238aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Murakami, M., et al. (2011) PLoS ONE 6 (6), E21242
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.15M NaCl,1mM DTT
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_058642
Uniprot Accession Number
Q9Y624
Species
Human
AA Sequence
Frequently Asked Questions
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