Recombinant human ERCC1 protein
ERCC1, also known as DNA excision repair protein ERCC-1, functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by uV light or formed by electrophilic compounds including cisplatin. Defects in ERCC1 are the cause of cerebro-oculo-facio-skeletal syndrome type 4 (COFS4) . Recombinant human ERCC1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
DNA excision repair protein ERCC-1, COFS4, RAD10, uV20
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
32.5 kDa (297aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Van Duin M., et al. (1986) Cell. 44:913-923; ; Grimwood J., et al. (2004) Nature. 428:529-535
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Scientific Category
Cancer
NCBI Accession Number
NP_001159521.1
Uniprot Accession Number
P07992
Species
Human
AA Sequence
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