Recombinant human PD-L1/B7-H1 protein (CD274)
CD274, also known as programmed cell death 1 ligand 1 (PDCD1L1), is involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. This protein interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Recombinant human CD274 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Programmed cell death 1 ligand, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
27.9 kDa (245aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
References & Citations
Dong H., et al. (1999) Nat. Med. 5:1365-1369; ; Freeman G.J., et al. (2000) J. Exp. Med. 192:1027-1034
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT
Scientific Category
Immunology
NCBI Accession Number
NP_054862
Uniprot Accession Number
Q9NZQ7
Species
Human
AA Sequence
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