Recombinant human PQBP1 protein
Polyglutamine binding protein 1, also known as PQBP1, is a transcription repressor that associates with polyglutamine tract-containing transcription regulators and causative genes for neurodegenerative disorders. PQBP-1 localizes to the nucleus and is present in neurons throughout the brain, with abundant levels in hippocampus, cerebellar cortex and olfactory bulb. PQBP-1 contains a WWP/WW domain that binds proline-rich motifs and a C2 domain that can influence Ca2+-dependent phospholipid signaling. Recombinant human PQBP1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Polyglutamine binding protein 1, MRX55, MRXS3, MRXS8, NPW38, RENS1, SHS
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
33 kDa (289aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Waragai M., et al. (1999) Hum Mol Genet. 8:977-987.; ; Waragai M C., et al. (2000) Biochem Biophys Res. 273: 592-595.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol, 1mM DTT
Scientific Category
Metabolism
NCBI Accession Number
NP_005701.1
Uniprot Accession Number
O60828
Species
Human
AA Sequence
Frequently Asked Questions
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