Recombinant human AKAP7 protein
AKAP7 (A-kinase anchor protein 7 isoform gamma isoform alpha), also known as AKAP18, belongs to the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAP 7 is expressed in brain, heart, lung, pancreas and skeletal muscle. AKAP 7 binds PKA to the plasma membrane, and permits functional coupling to the L-type calcium channel. Recombinant human AKAP7 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
A-kinase anchor protein 7 isoform gamma isoform alpha, AKAP15, AKAP18
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
11.5 kDa (105aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Trotter K.W., et al. (1999) J. Cell Biol. 147:1481-1492; ; Klussmann, E., et al. (2001) Kidney Int. 60: 446-449.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 50 mM NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_004833
Uniprot Accession Number
O43687
Species
Human
AA Sequence
MGQLCC FPFSRDEGKI SEKNGGEPDD AELVRLSKRL VENAVLKAVQ QYLEETQNKN KPGEGSSVKT EAADQNGNDN ENNRK
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Colloidal Gold Conjugated Monoclonal Antibody to Herpes Simplex II, 20nm
