Recombinant human AKAP7 protein
AKAP7 (A-kinase anchor protein 7 isoform gamma isoform alpha), also known as AKAP18, belongs to the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAP 7 is expressed in brain, heart, lung, pancreas and skeletal muscle. AKAP 7 binds PKA to the plasma membrane, and permits functional coupling to the L-type calcium channel. Recombinant human AKAP7 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
A-kinase anchor protein 7 isoform gamma isoform alpha, AKAP15, AKAP18
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
11.5 kDa (105aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Trotter K.W., et al. (1999) J. Cell Biol. 147:1481-1492; ; Klussmann, E., et al. (2001) Kidney Int. 60: 446-449.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 50 mM NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_004833
Uniprot Accession Number
O43687
Species
Human
AA Sequence
MGQLCC FPFSRDEGKI SEKNGGEPDD AELVRLSKRL VENAVLKAVQ QYLEETQNKN KPGEGSSVKT EAADQNGNDN ENNRK
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