Recombinant human NKIRAS2 protein

NFKB inhibitor interacting Ras-like 2 (NKIRAS2), also known as KBRAS2, is similar to the Ras-like small GTPases that associate with IkappaB. These Ras-like proteins, NKIRAS1 and NKIRAS2, interact with the PEST domains of IkB alpha and IkB beta and decrease their rate of degradation. NKIRAS2 shows 71% identity to KBRAS1. NKIRAS2 is an inhibitor of the transcription factor NF-kappaB. Recombinant human NKIRAS2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

NFKB inhibitor interacting Ras-like 2, kappaB-Ras2, KBRAS2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

24.0 kDa (215aa) confirmed by MALDI-TOF

Additionnal Information

NKIRAS2, NFKB inhibitor interacting Ras-like 2, kappaB-Ras2, KBRAS2, ATGP1519-10 µg, ATGP1519-20 µg, ATGP1519-50 µg, ATGP1519-100 µg, ATGP1519-250 µg, ATGP1519-500 µg, ATGP1519-1 mg, ATGP1519-10, ATGP1519-20, ATGP1519-50, ATGP1519-100, ATGP1519-250, ATGP1519-500, ATGP1519-1

References & Citations

May M J., et al. (1998) Immunol Today. 19:80-88.; ; Bos J L., et al. (1998) Mutat Res. 195:255-271.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl

Scientific Category

Signal Transduction

NCBI Accession Number

NP_001138399

Uniprot Accession Number

Q9NYR9

Species

Human

AA Sequence

MGKSCK VVVCGQASVG KTSILEQLLY GNHVVGSEMI ETQEDIYVGS IETDRGVREQ VRFYDTRGLR DGAELPRHCF SCTDGYVLVY STDSRESFQR VELLKKEIDK SKDKKEVTIV VLGNKCDLQE QRRVDPDVAQ HWAKSEKVKL WEVSVADRRS LLEPFVYLAS KMTQPQSKSA FPLSRKNKGS GSLDG