Recombinant human THAP1 protein

THAP domain-containing protein 1, also known as THAP1, is a 213 amino acid protein that localizes to the nucleoplasm and contains one THAPtype zinc finger, a conserved DNA-binding domain. It is a DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. THAP1 may also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. Recombinant human THAP1protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

THAP domain-containing protein 1, DYT6

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

27.5 kDa (237aa)

Additionnal Information

THAP1, THAP domain-containing protein 1, DYT6, ATGP1517-10 µg, ATGP1517-20 µg, ATGP1517-50 µg, ATGP1517-100 µg, ATGP1517-250 µg, ATGP1517-500 µg, ATGP1517-1 mg, ATGP1517-10, ATGP1517-20, ATGP1517-50, ATGP1517-100, ATGP1517-250, ATGP1517-500, ATGP1517-1

References & Citations

Roussigne M., et al. (2003) Oncogene 22:2432-2442.; ; Clouaire T., et al. (2005) Proc Natl Acad Sci. 102:6907-6912.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 10% glycerol, 1mM DTT, 0.2M NaCl

Scientific Category

Apoptosis

NCBI Accession Number

NP_060575

Uniprot Accession Number

Q9NVV9

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMVQSCS AYGCKNRYDK DKPVSFHKFP LTRPSLCKEW EAAVRRKNFK PTKYSSICSE HFTPDCFKRE CNNKLLKENA VPTIFLCTEP HDKKEDLLEP QEQLPPPPLP PPVSQVDAAI GLLMPPLQTP VNLSVFCDHN YTVEDTMHQR KRIHQLEQQV EKLRKKLKTA QQRCRRQERQ LEKLKEVVHF QKEKDDVSER GYVILPNDYF EIVEVPA